Blue Light • Red Light • Near-Infrared Light | Patient Education
TO BOOK AN APPOINTMENT, PLEASE CALL US AT (724) 225-2225
Blue Light • Red Light • Near-Infrared Light | Patient Education
TO BOOK AN APPOINTMENT, PLEASE CALL US AT (724) 225-2225
Blue Light
12 LEDs per wand
Penetration: Surface (0.5–2 mm)
Best for: Skin healing, lymphatics, antimicrobial
Red Light
5 LEDs per wand
Penetration: Superficial–Mid (~1 cm)
Best for: Tissue repair, blood, cellular metabolism
Near-Infrared
8 LEDs per wand
Penetration: Deep (up to 8 inches)
Best for: Joints, nerves, bone, brain, deep tissue
All three Firefly wavelengths work through the same fundamental mechanism — stimulating healing at the cellular level. The difference between each wavelength is how deeply the light penetrates and which tissues it targets. The Firefly Clinic Pro delivers all three simultaneously, treating multiple tissue depths in a single session.
1. Light Penetrates Skin & Is Absorbed by Mitochondria
Photons from the Firefly's blue, red, and near-infrared LEDs penetrate the skin. The light is absorbed by cytochrome c oxidase — the key photoreceptor enzyme inside every cell's mitochondria (the cell's powerhouse).
2. ATP Production Rapidly Increases
This light absorption energizes mitochondrial activity and dramatically boosts production of ATP (adenosine triphosphate) — the fuel cells need to repair damage, reduce inflammation, and regenerate tissue. Injured cells are energy-depleted; Firefly restores that energy.
3. A Cascade of Healing Signals Is Triggered
Rising cellular energy triggers powerful downstream effects: nitric oxide is released (widening blood vessels and improving circulation), pro-inflammatory cytokines are reduced, oxidative stress is neutralized, and stem cells are activated.
4. Deep Tissue Healing & Lasting Pain Relief
The combined result is accelerated tissue repair, reduced swelling and inflammation, nerve regeneration, improved oxygenation, and modulation of pain signals — all the way from the surface skin down to bone and neural tissue up to 8 inches deep.
The multi-wavelength, high-power design of the Firefly Clinic Pro makes it effective across a broad range of conditions — from acute pain and injury to complex neurological and autoimmune disorders.
Pain & Musculoskeletal
Neurological, Immune & Gut
* When combined with the optional F-scan and Function Generator add-on, the Firefly Clinic Pro can be programmed with precise frequencies to target specific pathogens, parasites, and bacteria identified in the scan.
What to Expect During Your Firefly Session
The Firefly Clinic Pro uses high-intensity LED technology — incoherent (non-laser) light — which is fundamentally safer than laser devices. Because the light is non-coherent, it spreads at distance rather than maintaining a focused beam, dramatically reducing eye and tissue hazard. It is non-thermal, non-ionizing, and does not cause tissue damage at therapeutic doses.
Do NOT apply Firefly light over these areas — always inform y our provider:
Firefly is safe for patients with:
Questions about your Firefly Clinic Pro treatment? Ask your provider at your next visit.
Firefly Clinic Pro is manufactured by Bales Photonics, Inc. — balesphotonics.com
This information is for educational purposes only and does not replace individualized medical advice from your healthcare provider.
References & Selected Scientific Literature
The following peer-reviewed publications support the clinical applications and mechanisms described in this handout. Full text is available via PubMed (pubmed.ncbi.nlm.nih.gov) using the PMID numbers listed.
Mechanisms of Action — Cytochrome C Oxidase, ATP & Cellular Signaling
1. Hamblin MR. Mechanisms and Mitochondrial Redox Signaling in Photobiomodulation. Photochem Photobiol. 2018 Mar;94(2):199-212. doi: 10.1111/php.12864. PMID: 29164625.
2. Hamblin MR. Mechanisms and Applications of the Anti-Inflammatory Effects of Photobiomodulation. AIMS Biophys. 2017;4(3):337-361. doi: 10.3934/biophy.2017.3.337. PMID: 28748217.
3. de Freitas LF, Hamblin MR. Proposed Mechanisms of Photobiomodulation or Low-Level Light Therapy. IEEE J Sel Top Quantum Electron. 2016;22(3):7000417. doi: 10.1109/JSTQE.2016.2561201. PMID: 28070154.
4. Hamblin MR, Liebert A. Photobiomodulation Therapy Mechanisms Beyond Cytochrome c Oxidase. Photobiomodul Photomed Laser Surg. 2022 Feb;40(2):75-77. doi: 10.1089/photob.2021.0119. PMID: 34818111.
Clinical Effectiveness — Systematic Reviews & Meta-Analyses
5. Kang J, Song Y. Effects of Photobiomodulation on Multiple Health Outcomes: An Umbrella Review of Randomized Clinical Trials. Syst Rev. 2025 Aug;14(1):175. doi: 10.1186/s13643-025-02902-3. PMID: 40082913.
6. Glass GE. Photobiomodulation: The Clinical Applications of Low-Level Light Therapy. Aesthet Surg J. 2021 May 18;41(6):723-738. doi: 10.1093/asj/sjab020. PMID: 33471046.
7. Barolet D, Christiaens F, Hamblin MR. Infrared and Skin: Friend or Foe. J Photochem Photobiol B. 2016 Feb;155:78-85. doi: 10.1016/j.jphotobiol.2015.12.014. PMID: 26708353.
Blue Light — Antimicrobial, Lymphatic & Surface Healing
8. Amin RM, Bhayana B, Hamblin MR, Dai T. Antimicrobial Blue Light Inactivation of Pseudomonas aeruginosa by Photo-Excitation of Endogenous Porphyrins. Lasers Surg Med. 2016 Jul;48(5):562-568. doi: 10.1002/lsm.22474. PMID: 26818884.
9. Dai T, Gupta A, Murray CK, Vrahas MS, Tegos GP, Hamblin MR. Blue Light for Infectious Diseases: Propionibacterium acnes, Helicobacter pylori, and Beyond? Drug Resist Updat. 2012 Aug;15(4):223-236. doi: 10.1016/j.drup.2012.07.001. PMID: 22846406.
Red Light — Tissue Repair, Collagen, Inflammation & Wound Healing
10. Wunsch A, Matuschka K. A Controlled Trial to Determine the Efficacy of Red and Near-Infrared Light Treatment in Patient Satisfaction, Reduction of Fine Lines, Wrinkles, Skin Roughness, and Intradermal Collagen Density Increase. Photomed Laser Surg. 2014 Feb;32(2):93-100. doi: 10.1089/pho.2013.3616. PMID: 24286286.
11. Tripodi N, Feehan J, Husaric M, Sidiroglou F, Apostolopoulos V. The Effect of Low-Level Red and Near-Infrared Photobiomodulation on Pain and Function in Tendinopathy: A Systematic Review and Meta-Analysis of Randomized Control Trials. BMC Sports Sci Med Rehabil. 2021;13(1):91. doi: 10.1186/s13102-021-00306-z. PMID: 34362434.
12. Tchanque-Fossuo CN, Ho D, Dahle SE, et al. Low-Level Light Therapy for Treatment of Diabetic Foot Ulcer: A Review of Clinical Experiences. J Drugs Dermatol. 2016;15(7):843-848. PMID: 27391639.
Near-Infrared Light — Deep Tissue, Nerve, Bone & Neurological Applications
13. Salehpour F, Mahmoudi J, Kamari F, et al. Brain Photobiomodulation Therapy: A Narrative Review. Mol Neurobiol. 2018 Aug;55(8):6601-6636. doi: 10.1007/s12035-017-0852-4. PMID: 29327206.
14. Liebert A, Capon W, Pang V, et al. Near-Infrared Stimulation in Psychiatric Disorders: A Systematic Review of Efficacy and Biological Mechanisms. Brain Sci. 2025;15(3):262. doi: 10.3390/brainsci15030262. PMID: 40149783.
15. Alayat MS, Atya AM, Ali MM, Shosha TM. Long-Term Effect of High-Intensity Laser Therapy in the Treatment of Patients with Chronic Low Back Pain. Lasers Med Sci. 2014 May;29(3):1065-73. doi: 10.1007/s10103-013-1472-5. PMID: 24178907.
Firefly Clinic Pro Device — Referenced Conditions (Bales Photonics Research Page)
16. Yeh SW, Hong CH, Shih MC, Tam KW, Huang YH, Kuan YC. Low-Level Laser Therapy for Fibromyalgia: A Systematic Review and Meta-Analysis. Pain Physician. 2019;22(3):241-254. PMID: 31151333.
17. Raeissadat SA, Rayegani SM, Sadeghi F, et al. Efficacy of Photobiomodulation Therapy Versus Corticosteroid Injection in Plantar Fasciitis. Lasers Med Sci. 2019;34(7):1363-1371. doi: 10.1007/s10103-019-02731-8. PMID: 31107161.
18. Yagci N, Duymaz T. Effectiveness of Low-Level Laser Therapy in Carpal Tunnel Syndrome. J Back Musculoskelet Rehabil. 2020;33(2):247-252. doi: 10.3233/BMR-170855. PMID: 31742366.
19. Brosseau L, Wells GA, Poitras S, et al. Ottawa Panel Evidence-Based Clinical Practice Guidelines on Therapeutic Massage for Neck Pain. J Bodyw Mov Ther. 2012. [Back pain photobiomodulation reference: PMID: 30334124.]
20. Hamblin MR, et al. Brain Photobiomodulation for Neurodegenerative Disease (Parkinson's and Alzheimer's). [Bales Photonics reference — full text: balesphotonics.com/research]. Accessible via: pubmed.ncbi.nlm.nih.gov/29131369/. PMID: 29131369.
Skin Conditions, Wound Healing & Comprehensive Reviews
21. Sikorska M, Zalesinska A, Szukalski A, et al. Unlocking the Power of Light on the Skin: A Comprehensive Review on Photobiomodulation. Int J Mol Sci. 2024 Apr;25(8):4483. doi: 10.3390/ijms25084483. PMID: 38674068.
22. Serrage H, Heiskanen V, Hamblin MR, et al. Under the Spotlight: Mechanisms of Photobiomodulation Concentrating on Blue and Green Light. Photochem Photobiol Sci. 2019;18(8):1877-1909. doi: 10.1039/c9pp00089e. PMID: 31241051.
23. Furchgott RF, Zawadzki JV. The Obligatory Role of Endothelial Cells in the Relaxation of Arterial Smooth Muscle by Acetylcholine. Nature. 1980;288:373-376. [Nobel Prize 1998 — Nitric Oxide and PBM mechanism foundation].
Additional research is available at: balesphotonics.com/research | pubmed.ncbi.nlm.nih.gov